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considered electron microscopy characteristics of the urothelium and demonstrated defects in umbrella cells (denudation, increased pleomorphism, and decreased microplicae of the cell membrane) in patients with IC/BPS (diagnosed using ESSIC 2008 criteria) compared with controls

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This study design differs from the single-dose lean-rat experiment in species, dosing schedule, duration, and endpoint, and the ED 50 values from the two studies should not be treated as directly comparable or rank-ordered across studies

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