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The 72-week STEP UP T2D trial investigated semaglutide 7.2 mg in 512 adults with obesity and type 2 diabetes, with the primary objective to demonstrate superiority of semaglutide 7.2 mg against placebo on weight loss

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Adv Ther 39 , 31803198 (2022)

Semaglutide significantly improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and promoted substantial weight loss in patients with antipsychotic-induced metabolic disturbances

The combination of GH-driven lipolysis and improved body composition creates a feedback loop where lean muscle becomes more visible as fat recedes