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Its approval rests on two multicenter, randomized, double-blind, placebo-controlled trials in patients with erythropoietic protoporphyria one conducted in Europe and one in the United States in which the afamelanotide implant increased the amount of pain-free time patients could spend in sunlight and was generally well tolerated, with adverse events that were mostly mild

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In addition to the electron respiratory chain, other sites of oxidative stress exist within the mitochondria

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Bell A., Gagnon A., Grunder L., Parikh S.J., Smith T.J., Sorisky A

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