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In recent years, we added an epigenetic component to the Allostasis/Allostatic load model to describe how non-shared environmental experiences may set each individual on a somewhat different trajectory of development that determines either adaptive or maladaptive responses (behavior, systemic function and vulnerability to disease) to subsequent novel experiences as the life course unfolds [20]

Comparative Biochemistry & Physiology Part B Biochemistry & Molecular Biology 154 , 121133 (2009)

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A still unsolved issue, connected with the role of carnitine in modulating gene expression (Figure 1) is the link between mitochondria and nucleus: acetylcarnitine produced in mitochondria would reach the nucleus providing acetyl units (Figure 2)