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Published 2026 Jan 16

The first major hurdle that became apparent shortly after the first IGF-1 assay was the discovery of IGFBPs, the presence of which significantly reduced the levels of immunoreactive IGF-1 in samples leading to misleadingly low results

7.4 Results: antioxidant enzyme activities and levels in CF The chronic inflammation and recurrent infections inherent to CF create a state of heightened oxidative stress, leading to investigations into the status of the antioxidant enzyme defense system

Author Contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis, and interpretation, or all these areas