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This coupled transcriptomemetabolome network enables newly infected B-cells to reprogram energy, redox, and nucleotide metabolism in a manner not fully reproduced by CD40L+IL4 stimulation, establishing a metabolic architecture that likely facilitates adaptation to hypoxic microenvironments and progression toward immortalization
The best treatment for a 32-year-old patient with a BMI of 31 is not always the same as the best treatment for a 52-year-old patient with a BMI of 46, diabetes, sleep apnea, and years of weight cycling
& Boucrot, E
Cancer Cell 2010