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Despite the established efficacy of sorafenib and regorafenib in advanced HCC, resistance frequently develops with prolonged use, adversely influencing the subsequent course of the disease [88]
Mesotherapy or intradermotherapy is a minimally invasive, nonsurgical procedure that consists of multiple intradermal injections of small quantities of various substances in solution, applied directly to the area to be treated.1 The technique was first described in 1958 by Pistor for the treatment of joint and muscle pain
Nature 447 , 11161120 (2007)
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