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For example, transcriptomic analyses of hibernator-derived mammalian cells have identified glutathione peroxidase 4 (Gpx4) as a key mediator of cold resistance, highlighting the role of redox regulation in low-temperature survival (41)

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Specifically, IKE exerts anti-cancer activity by inducing lipid peroxidation and upregulating ferroptosis genes, including SLC7A11 (73)

doi: 10.1016/j.metabol.2013.07.006

Remove the needle & syringe and discard 7