It has been reported that IGFBP-3 binds to a nuclear receptor, 9-cis retinoic acid receptor-alpha (RXR-), which interacts with peroxisome proliferator activated receptor-gamma (PPAR-), a nuclear protein involved in the regulation of glucose and lipid metabolism [175, 176]
eGFR, estimated glomerular filtration rate
PMID 29983246
Metabolism: Clinical and Experimental 2013:11991205
Though there appear to be no risk and few symptoms associated with too much B12, its wise to keep your level within the upper limit of the standard test range.
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