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Moreover, smooth-fitting curve analysis identified a threshold effect: below 358.7 pg/mL, each 10 pg/mL increase in vitamin B12 was associated with a 4.4% increase in clinical pregnancy rate (OR = 1.04, P = 0.03), beyond which no further benefit was observed

Promotes gut microbiome balance

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Its potential benefit for acne is theoretical and based on its systemic effects, such as reducing inflammation and healing the gut, which are known underlying contributors to acne