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In vitro evidence suggests that L-carnitine may modulate insulin-like signaling pathways in hepatocytes, including IGF1-associated AKT and p70 S6 kinase signaling

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Apr 2010;2(4):170-173

In vivo bioequivalence and in vitro similarity factor (F2) for dissolution profile comparisons of extended release formulations: how and when do they match

Through their forkhead box domains FOXO transcription factors can specifically recognize two different DNA-response elements, the DAF-16 binding element (DBE) 5-GTAAACAA-3 and the insulin-responsive element (IRE) 5-(C/A)(A/C)AAA(C/T)AA-3, whose core sequence is 5-(A/C)AA(C/T)A-3 [11,12,13,14,15]