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The biggest risk is something that can be called a silent restriction. When the medication mutes your stomachs physical hunger cues, its easy to accidentally slip into a state of under-fueling, which can be mimicking the very restrictive patterns that often trigger a binge cycle in the first place

Updated January 13, 2026

10.1146/annurev-biochem-060815-014830 162 NewtonK.StrasserA.KayagakiN.DixitV

We first studied hyperpolarized [1- 13 C]dehydroascorbate in the normal rat brain, demonstrating its robust conversion to [1- 13 C]vitamin C, consistent with rapid transport of the oxidized form across the blood-brain barrier

Wolf, K., Alexander, S., Schacht, V., Coussens, L

Not Rotating Sites: This can lead to skin irritation