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The SELECT trial demonstrated a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes [1] [2]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Buonocore D., Grosini M., Giardina S., Michelotti A., Carrabetta M., Seneci A., Verri M., Dossena M., Marzatico F

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5 Discussion: perspective and open questions While the identification of RAiNs (Sebastian et al., 2012) and VAPB ( The role of calcium signaling at these interfaces represents another pressing open question