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doi: 10.1212/CON.0000000000001103 [PubMed] 35449037 Bilbao-Meseguer I, Barrasa H, Rodrguez-Gascn A, Asn-Prieto E, Maynar J, Snchez-Izquierdo J, Solins M, Isla A

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Recent studies conducted within our group [83] have focused on clarifying the coordinated effects of fasting, re-feeding and exendin-4 administration on the activity of AMPK and S6K in the VMH and LH

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(2015) described the development of angiotensin IV analogs including Dihexa and their HGF/c-Met potentiation mechanism (PMID: 25455861) Expression of Concern: The landmark 2012 paper describing Dihexa's cognitive effects received an expression of concern from the journal (PMID: 34551989), citing data integrity issues including questioned Western blot images Retraction: A follow-up paper from the same research group was retracted (PMID: 40312093), further undermining the evidence base for Dihexa's reported effects No Human Studies: No clinical trials, pharmacokinetic studies, or safety assessments have been conducted in humans Limited Independent Replication: The core claims about Dihexa's cognitive-enhancing effects have not been independently replicated by groups outside the original laboratory The Evidence Gap: This comparison starkly illustrates the difference between a compound with decades of clinical validation (Cerebrolysin) and one with provocative preclinical data undermined by integrity concerns (Dihexa)