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In addition, it was reported that future biomarker studies must consider exposure to antidepressants, which is the main cause of heterogeneity in depression subgroups

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However, the increase in erythrocyte omega-3 index was negatively correlated with that of brain because free EPA increased the omega-3 content of erythrocytes but not the brain, similar to the effects of TAG-DHA

This led to further investigations and the eventual development of bremelanotide, a related compound used to treat sexual dysfunction