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Estrogen signaling multiple pathways to impact gene transcription

The role of glycine supplementation in improving GSH status warrants further research given its broad, beneficial influence on the GSH pathway

has received educational honoraria from Novo Nordisk and Ipsen, and has been supported to attend meetings/travel by Novo Nordisk, Ipsen, and Gilead

Along this line, altered expression or function of these ion channels and receptors has been correlated with impaired receptivity, implantation failure and linked to several endometrial pathologies, making them interesting targets for diagnostic and therapeutic interventions [39, 45, 46]

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However, they commonly face challenges such as low bioavailability, complex action targets, difficulty achieving effective therapeutic concentrations in target tissues, and rapid in vivo metabolism