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The mechanism isn't fully mapped, but it likely involves circadian modulation of vagal afferent sensitivity

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After all, people on the high-fat plan limit themselves to 20 to 50 grams of carbs per day, which naturally cuts out whole grains, legumes, most fruits and dairy, and starchy vegetables

Regular monitoring and appropriate dose adjustment of levothyroxine to maintain TSH within the reference range (typically 0.4-4.0 mU/L, though individualised targets may apply) is essential before implementing additional weight management interventions

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