Effect of glutathione on [ 3 H]dopamine release from the mouse striatum evoked by glutamate receptor agonists
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Ultrasound-driven MNMs have better drive speeds in in vivo body fluid environments (e.g., lymph fluid and blood) than other drive modes [138, 139]
We examine the role of receptor binding kinetics and -arrestin-biased signaling in the observed trafficking profiles, identifying a linked set of agonist characteristics optimally suited for insulin secretion, not shared by GLP-1R agonists in the current clinical use
May 2012;8(3):183-190
Only through this holistic and forward-thinking approach can we hope to develop therapies that go beyond modifying disease progression, preserving, and potentially restoring neural integrity in the human brain