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doi:10.1038/s41598-024-65310-y Neelakantan H, Hommel JD, Watowich SJ, et al

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Estrogen has been shown to upregulate endogenous MOTS-c expression in preclinical models, which may partly explain why metabolic deterioration accelerates in perimenopause when estrogen falls precipitously [2]

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The results, published in Cosmeceuticals and Active Cosmetics (Marcel Dekker), documented improvements across every measured parameter: skin laxity, clarity, firmness, fine lines, coarse wrinkles, mottled pigmentation, and skin density