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have confirmed that the increase of circulating TMAO downregulates IL-10 and promotes vascular inflammation, contributing to endothelial dysfunction by mouse experiments (55)

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Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion

Mar 2022;179:108970

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In metabolic diseases, TMAOs pathogenic effects are potentiated