Most Common Side Effects When starting Horizant at the recommended RLS dose (600 mg), the most frequently reported side effects are: These side effects occur because Horizant slows nervous system activity
These can include: Nausea Diarrhea or constipation Stomach pain, bloating, or gas Heartburn or burping Loss of appetite Dizziness or fatigue Some symptoms are more severe, and they require immediate medical attention
You might wake slightly nauseous, but the worst will have passed
ONeil PM, Aroda VR, Astrup A, et al
2023;25(2):485-496 5 Rubino D, Abrahamsson N, Davies M, et al
In February 2025, the FDA gave a deadline for pharmacies to stop producing compounded semaglutide, because there is no longer a drug shortage of Ozempic