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Abstract Objectives The available medications for diabetes mellitus (DM) are not sufficient to reverse the pathophysiological abnormalities and complications associated with the disease

Consequently, NRF2 activity increases, leading to the elevated expression of antioxidant enzymes such as glutathione S-transferase, NAD(P)H quinone oxidoreductase 1, and heme oxygenase-1 (260)

Cells deficient in GPx1 generated more ROS, in the presence and absence of TNF, as measured intracellularly by DCF fluorescence or extracellularly, as measured by Amplex Red detection of hydrogen peroxide in the media [6]

The possible roles of -alanine and L-carnosine in anti-aging