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Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

Acute hepatitis after starting zinc therapy in a patient with presymptomatic Wilson's disease

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Notably, DJX-A-KM which uses acrylamide as the covalent warhead for potential E3 ligase recruitment showed robust activity, achieving ~90% KRAS G12C degradation after 8 h of treatment at 40 nM