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Several studies have shown that acute exposure of mice to e-cigarette aerosols increases the number of both CD4 + and CD8 + T cells in the lung(38, 49, 71), which aligns with transcriptional analyses of lungs showing upregulation of genes involved in immune signaling for T cell migration(72, 73) (Figure 5)

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Hellberg V, Wallin I, Eriksson S, Hernlund E, Jerremalm E, Berndtsson M, Eksborg S, Arnr ESJ, Shoshan M, Ehrsson H (2009) Cisplatin and oxaliplatin toxicity: importance of cochlear kinetics as a determinant for ototoxicity