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FIGURE 4 FIGURE 5 3.3 L-carnitine counteracted lenvatinib-induced protein synthesis inhibition in C2C12 myocytes We have shown that lenvatinib inhibits global protein synthesis in C2C12 myocytes at concentrations 100 nM, which is equivalent to the trough plasma concentration in patients with HCC (Supplementary Figure S1)

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Apoptosis Initiation: Once liberated, p53 translocates to the mitochondria and activates BAX/BAK, triggering intrinsic apoptosis (cell death) specifically in the senescent cell

Ann Pharmacother 56(8):922926

doi: 10.1016/j.foodres.2022.112309 [DOI] [PubMed] [Google Scholar] 22

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