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The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

While it may not be as widely recognized as nausea or diarrhea, feeling cold can still be an uncomfortable and concerning symptom for those who experience it

Fatigue and energy changes Some people experience fatigue on GLP-1 medications , especially during the first few weeks

Additionally, aftercare instructions may include recommendations for hydration, diet, and any other relevant guidelines to optimize the benefits of the therapy

Weissman PN, Carr MC, Ye J, et al

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