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The goal is to find the lowest possible dose that elicits the desired effect you're studying, as this will almost always correspond with the lowest incidence of KLOW side effects

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These studies should also aim to establish the optimal dose when metformin is used alongside current TB therapies, as well as its potential role in shortening treatment duration and enhancing prophylactic control of TB

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Overexpression of miR-15a-3p increases ROS, intracellular Fe 2 , and malondialdehyde accumulation in CRC cells by binding to the 3UTR of GPX4 to suppress its expression [146]