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Folate is needed for the spinal cord to develop correctly

Given the short half-life, twice-daily dosing provides additional exposure compared to once-daily protocols at the same total dose

Those following vegetarian or vegan diets, individuals with absorption issues such as Crohns or celiac disease, people taking certain medications, or older adults may be at greater risk of deficiency

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(Vitamin B12 is found in meats and animal products like eggs.) Poor absorption When patients consume enough Vitamin B12 and Folate, but their body can not absorb or use the vitamins normally