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10.1152/ajplung.90369.2008

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Metformin activates AMPK through the lysosomal pathway

HCQ was administered at a dose of 200 mg three times daily for 10 days to treat patients with confirmed cases of COVID-19 infection 5

Lei Fan et al

Also, large porous particles are less susceptible to macrophage uptake, thereby enhancing pulmonary drug retention and supporting sustained release of inhaled therapeutics 103,104,105