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Immunohistochemistry confirmed arginase-1 in the lungs and macrophages in the BALF and demonstrated arginase-1 mRNA expression and p38 MAPK phosphorylation were inhibited in peritoneal macrophages stimulated with IL-4 [66]

Expected Timeline for Symptom Improvement It may take a few weeks to a few months to see symptom improvements with oral B12

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Huguet, Franoise

Accessed 08/18/21

Longitudinal studies in animal models and post-mortem human tissues are needed to determine whether microglial iron overload is a cause or consequence of -syn pathology, and to identify the disease stage at which glial modulation is most therapeutically beneficial