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No receptor-mediated adverse events (e.g., cardiovascular effects, endocrine disruption) have been reported, consistent with NNMT's limited expression outside metabolic tissues

Chronic stimulation may alter pulse amplitude, receptor sensitivity, glucose metabolism, and endocrine balance

Lighezan L, Meiri D, Breiman A, Neagu A

Papilledema associated with dialysis disequilibrium syndrome

Some had virtually no DPA, while others provided nearly 100 mg per serving