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[7] N-acetylated LKKTETQ (Ac-LKKTETQ) and several of its metabolites can be detected in equine urine and plasma following administration of TB-500 using liquid chromatographymass spectrometry, with metabolite profiling enabling identification of peptide-derived products in biological samples

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Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice

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