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Simultaneously, BPC-157 modulates the nitric oxide (NO) system bidirectionallyincreasing NO in deficiency states and decreasing it in excesswhich is critical for vascular tone and inflammation resolution at injury sites

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Since either metformin or GLP-1 analogue has vascular protective effects 7,24 , we reasonably hypothesized that this combination therapy might also have a synergistic protective effect on endothelial function