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But contrary to popular thought, low B12 might leave you straining

(1982) examined the contents of three multivitamin preparations and, after incubating them in water at 37C (body temperature) for 2 hours, found that 20% to 90% of the B12 had degraded to inactive analogs

Quick Answer: Most Vitamin B12 Injections do not need to be refrigerated

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Mix gently : Swirl the vial until the powder fully dissolves