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Patients with active or suspected cancer should obtain clearance from their oncologist before beginning treatment

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In certain investigations, GHRH-like compounds and GHS-R activators were associated with apparent increases in pulsatile growth hormone secretion20-fold and 47-fold above baseline, respectively

Nonetheless, further data are needed to assess the safety of retatrutide on muscle mass, particularly in populations at risk for sarcopenia, where caution is warranted