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27 Tyr 10 and Ile 12 from GIP are used in MAR709 and Ile 12 plays a key role in the activation of GIPR 15

Role of leptin in the regulation of glucagon-like peptide-1 secretion

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Furthermore, occupation of the S2 extensive subsite not only increases inhibitory potency but also enhances selectivity toward DPP4 over related enzymes