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However, in individuals with sensitive airways, the act of inhaling this specific compound can cause a localized reaction

10.1007/s11064-015-1513-5 94 PerinelliD

(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

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It inhibits the transcription of SLC7A11, leading to a reduction in cystine uptake and GSH production, thereby amplifying the cell's vulnerability to ferroptosis [61]

J Neuroscience: Official J Soc Neurosci