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GSH is converted to its oxidized form (GSSG) by donating its electrons to neutralize free radicals

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Due to the age-related leakage of ROS from mitochondrial complexes and the TCA cycle [78], coupled with the ROS from NAD(P)H oxidoreductases [2] and A processing [79], we predict that GTP levels may shift reductive from an oxidative environment which was remediated by Nrf2 induction with EGCG