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This disruption allows endotoxins and pro-inflammatory molecules to translocate into the systemic circulation, thereby influencing CNS function via the gutbrain axis
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5,6 For example, free radicals play a role in detoxification of xenobiotics by oxidizing enzymes, in killing of microorganisms by macrophages and cytotoxic lymphocytes, and in the generation of prostaglandins and leukotrienes, which activate oxygenases (e.g., cyclooxygenases and lipoxygenase) and thus act as modulators of the inflammatory response
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