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Chatterjee A. Reduced glutathione: a radioprotector or a modulator of DNA-repair activity?. Nutrients. 2013;5(2):525-542. Published 2013 Feb 7. doi:10.3390/nu5020525doi:10.3390/nu5020525

The major organic solvent soluble metabolites of benzo(a)pyrene identified in the cultured cells were trans-7,8-dihydro-7,8-dihydroxybenzo(a)pyrene, 9-hydroxybenzo(a)pyrene, and 3-hydroxybenzo(a)pyrene, although small amounts of trans-4,5-dihydro-4,5-dihydroxybenzo(a)pyrene, benzo(a)pyrene-quinones, and trans-9,10-dihydroxybenzo(a)pyrene were also present

Enhanced metabolic stability

Genetic predisposition is one input

Patients on maintenance doses retained 70 to 85% of their peak weight loss at two years, compared to 40 to 60% retention for those who stopped completely but implemented lifestyle changes, and less than 30% for those who stopped without significant lifestyle modification

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