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Diabetologia 65(Suppl 1):S289S289 Patel H, Khunti K, Rodbard HW et al (2022) Tirzepatide-induced weight loss in type 2 diabetes is independent of nausea, vomiting, or diarrhoea

BioMed Research International , 2015, 648108

Receptors for GLP-1 are located on enteric neurons that exhibit increased action potential firing in primary culture following the application of GLP-1, which may, for example, inhibit local muscle tone as part of the ileal brake (96)

The stable drug levels prevent the peaks and valleys seen with medications that clear quickly, resulting in more uniform metabolic effects and better tolerability for most users

I suspect that the productivity benefits went away because I wasn't eating enough, and it takes a few weeks for your body to run out of fuel

Brands that build product systems spanning this journey, from initial appetite adjustment through long-term weight management to potential drug discontinuation, will build loyalty that transcends any single SKU