The study further showed that restoring mitochondrial biogenesis through PGC-1 overexpression enhances T cell metabolic fitness and anti-tumor function, highlighting the critical role of metabolic regulation in determining T cell efficacy in the TME (84)
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Nevertheless, therapeutic hypothermia is only partially effective (5760), and many infants with HIE remain at substantial risk of death or severe long-term neurodevelopmental impairments (55)
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