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In diet-induced obese mice bearing subcutaneous KPN1.1 tumors, liraglutide reduced tumor burden, whereas in an autochthonous KRAS/p53-driven non-small cell lung cancer model, semaglutide improved tumor control and survival

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Variants in GLP1R (the GLP-1 receptor itself), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

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