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Additionally, some studies, such as those involving oral doses of PBF-677 in healthy volunteers, employed dose-escalation methodologies to determine the maximum tolerated dose while closely monitoring for potential side effects (NCT02639975)

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A key differentiator of Mardrigals resmetirom is that in a pivotal Phase 3 trial, it achieved both primary endpoints of NASH resolution and reduction in fibrosis (MAESTRO-NASH), the two liver histological improvement endpoints the FDA has proposed as reasonably likely to predict clinical benefit

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An article on the link between the chemical carnitine, TMAO and heart disease is published in the journal Nature Medicine .

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