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Pathogenicity predictions for missense variants were conducted using MutPred2 [35] ( and Missense3D [36] ( For MutPred2 analysis, amino acid sequences in FASTA format were retrieved from NCBI Protein database [37]

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All use must comply with applicable laws, regulations, and laboratory safety standards.

Weghuber D, Barrett T, Barrientos-Prez M, Gies I, Hesse D, Jeppesen OK et al