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4c, replacement of the first six residues of GLP-2 by those of GLP-1 (i.e., double mutant D 3P E and S 5P T) decreased cAMP accumulation by 12-fold compared to the native peptide, suggesting that subtle substitution may directly alter receptor activation

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What Makes This Research Different The addiction treatment field has seen promising drug candidates before

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The purpose of our trial here at CU Anschutz is really to help inform, especially in pediatric populations, how we leverage the brain and subsequent behaviors to create and develop different clinical protocols, so maybe adolescents don't have to be on these drugs the rest of their lives, Shapiro says