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doi: 10.1016/j.bbrc.2016.10.099 130 MehraSSahaySMajiSK

This condition represents a significant adverse drug reaction that may lead to multiorgan failure and potentially fatal outcomes ( 4.2 Oxidative stress As linezolid inhibits mitochondrial protein synthesis, it may alter its own metabolism, resulting in a higher chance of non-negligible toxicity ( The present study found that linezolid induced a state of oxidative stress in both liver and kidney tissues via increasing hepatic and renal NO and MDA content at the expense of tissue GSH and serum catalase activity, which was found to be depleted