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In day and night creams, it can be used at lower to moderate levels to provide long-term antioxidant protection, improve skin tone uniformity, and enhance anti-aging benefits such as firmness and radiance

[DOI] [PubMed] [Google Scholar] 70.Tosukhowong P., Boonla C., Dissayabutra T., Kaewwilai L., Muensri S., Chotipanich C., Joutsa J., Rinne J., Bhidayasiri R

[Abstract]2025 Dec;333(Pt 1):148831

G protein-coupled estrogen receptor enhances melanogenesis via cAMP-protein kinase (PKA) by upregulating microphthalmia-related transcription factor-tyrosinase in melanoma