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Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone

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In contrast, mice treated with a GH antagonist made by replacing a single amino acid in the GH chain did not show an increased lifespan

G., Watt, R

Animals synthesize ThDP by diphosphorylation of thiamine in the thiamine diphosphokinase (or thiamine pyrophosphokinase, TPK)-catalyzed reaction (Figure 3A)

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