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34 In addition, a greater number of cells containing lipofuscin, a matrix of lysosomal degradation products and a marker for oxidative stress, was found in BA22 in autism compared with control samples

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DJ-1 functions as a bona fide negative modulator of ferroptosis by sustaining S-adenosyl homocysteine hydrolase activity through altering its interaction with the negative regulator adenosylhomocysteinase like protein 1, thereby maintaining the transsulfuration pathway-mediated biosynthesis of homocysteine and subsequent GSH synthesis (157)

1 Introduction Digestive cancers pose a significant threat to patients life, usually along with poor prognosis